Mac and Cheese Meatloaf Casserole Recipe
Introduction
Indulge in the ultimate comfort food experience with this Mac and Cheese Meatloaf Casserole. Combining creamy macaroni and cheese with a savory meatloaf base, this dish is perfect for cozy family dinners or potlucks. Easy to prepare and sure to please, it’s a fantastic twist on classic favorites.

Ingredients
- 1 lb ground beef
- 1/2 cup diced onion
- 1/2 cup breadcrumbs
- 1 large egg
- 1/4 cup milk (for meatloaf)
- 1 tsp salt
- 1/2 tsp pepper
- 2 cups uncooked macaroni
- 2 cups shredded cheddar cheese
- 2 tbsp butter (for cheese sauce)
- 2 tbsp flour
- 2 cups milk (for cheese sauce)
- 1/2 tsp paprika
- 1/2 tsp dry mustard
- 1/2 tsp salt (for cheese sauce)
- 1/4 tsp pepper (for cheese sauce)
Instructions
- Step 1: Preheat your oven to 350°F (175°C).
- Step 2: In a mixing bowl, combine ground beef, diced onion, breadcrumbs, egg, 1/4 cup milk, 1 tsp salt, and 1/2 tsp pepper. Mix well until fully combined, then press the mixture into the bottom of a greased baking dish.
- Step 3: Bake the meatloaf layer in the preheated oven for about 20 minutes.
- Step 4: While the meatloaf bakes, cook macaroni according to package directions. Drain and set aside.
- Step 5: For the cheese sauce, melt butter in a medium saucepan over medium heat. Stir in flour and cook for about one minute.
- Step 6: Gradually whisk in 2 cups milk and cook until the sauce thickens. Stir in 1/2 tsp salt, 1/4 tsp pepper, paprika, and dry mustard. Add 1½ cups of shredded cheddar cheese and stir until melted.
- Step 7: Combine the cooked macaroni with the cheese sauce until well coated. Pour this mixture over the partially baked meatloaf layer. Sprinkle the remaining 1/2 cup cheese on top.
- Step 8: Return the casserole to the oven and bake for an additional 25 minutes, or until the cheese is melted and bubbly.
Tips & Variations
- Use high-quality shredded cheese for a creamier, richer flavor.
- Cook macaroni just until al dente to avoid mushy pasta after baking.
- Let the casserole rest for 10 minutes before serving to help it set.
- Try mixing in other cheeses like Gouda or Monterey Jack for unique flavors.
- Add vegetables such as spinach or bell peppers to the meatloaf or cheese sauce for extra nutrition.
Storage
Store any leftovers in an airtight container in the refrigerator for 3-5 days. For longer storage, portion the casserole into individual servings and freeze for up to 2-3 months. To reheat, warm in a 350°F (175°C) oven covered with foil for about 20 minutes, or microwave in a covered dish until heated through.
How to Serve

Serve this delicious recipe with your favorite sides.
FAQs
Can I use different types of meat?
Yes! Ground turkey, lamb, or plant-based meat alternatives can be used. Just ensure the meat is cooked thoroughly.
How do I make this dish vegetarian?
Use plant-based ground meat alternatives and substitute vegetable broth or plant-based milk in the cheese sauce to make a vegetarian version.
PrintMac and Cheese Meatloaf Casserole Recipe
Indulge in the ultimate comfort food experience with our Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup. This delightful dish features layers of creamy macaroni and cheese paired with a savory meatloaf, creating a harmonious blend that’s perfect for family dinners, potlucks, or any cozy gathering. Easy to prepare and kid-friendly, this casserole is sure to become a favorite in your household. Customize it with your choice of vegetables or cheese for a personal touch.
- Prep Time: 15 minutes
- Cook Time: 45 minutes
- Total Time: 1 hour
- Yield: Serves approximately 6
- Category: Main
- Method: Baking
- Cuisine: American
Ingredients
For the Meatloaf Layer
- 1 lb ground beef
- 1/2 cup diced onion
- 1/2 cup breadcrumbs
- 1 large egg
- 1/4 cup milk
- 1 tsp salt
- 1/2 tsp pepper
For the Mac and Cheese Layer
- 2 cups uncooked macaroni
- 2 cups shredded cheddar cheese
For the Cheese Sauce
- 2 tbsp butter
- 2 tbsp flour
- 2 cups milk
- 1/2 tsp salt
- 1/4 tsp pepper
- 1/2 tsp paprika
- 1/2 tsp dry mustard
Instructions
- Preheat the Oven: Preheat your oven to 350°F (175°C) to ensure it reaches the ideal temperature for baking the casserole evenly.
- Prepare Meatloaf: In a mixing bowl, combine ground beef, diced onion, breadcrumbs, egg, 1/4 cup milk, salt, and pepper. Mix thoroughly until all ingredients are well incorporated. Press this mixture firmly into the bottom of a greased baking dish, forming an even layer.
- Bake Meatloaf: Place the baking dish in the preheated oven and bake for about 20 minutes. This will partially cook the meatloaf layer, preparing it for the casserole assembly.
- Cook Macaroni: While the meatloaf is baking, cook the macaroni according to package directions until al dente. Drain the pasta well and set aside to prevent overcooking.
- Make Cheese Sauce: In a medium saucepan over medium heat, melt the butter. Stir in the flour and cook for about one minute to form a roux. Gradually whisk in 2 cups of milk, continuing to cook and stir until the sauce thickens. Season with salt, pepper, paprika, and dry mustard. Add 1½ cups of shredded cheddar cheese and stir until the cheese melts completely into a smooth sauce.
- Combine Macaroni and Cheese Sauce: Mix the cooked macaroni into the cheese sauce until the pasta is well coated. Pour this cheesy macaroni mixture evenly over the partially baked meatloaf in the baking dish. Sprinkle the remaining ½ cup of shredded cheddar cheese on top for a bubbly, golden finish.
- Bake Again: Return the casserole to the oven and bake for an additional 25 minutes, or until the cheese on top is melted, bubbly, and slightly golden around the edges.
- Rest Before Serving: Allow the casserole to rest for about 10 minutes after removing it from the oven. This helps the casserole set, making it easier to slice and serve.
Notes
- Use high-quality ground beef for the best flavor and texture; avoid lean options that might dry out.
- Cook macaroni just until al dente, as it will continue cooking in the oven to avoid mushiness.
- Season both the meatloaf and cheese sauce well to enhance overall flavor.
- Let the casserole rest for 10 minutes after baking to firm up for easier serving.
- Use freshly shredded cheese rather than pre-packaged to ensure a smooth melt.
- Feel free to add vegetables such as spinach or bell peppers to meatloaf or cheese sauce for extra nutrition.
- For variation, try mixing different cheeses like mozzarella or Gouda in the cheese sauce.
Keywords: Comfort food, Mac and cheese, Meatloaf casserole, Cheesy casserole, Layered casserole, Family dinner, Kid-friendly recipe, Cheddar cheese, Pasta bake, Easy weeknight meal

